The poem
Whate'er is Born of Mortal Birth, Must be consumed with the Earth To rise from Generation free: Then what have I to do with thee?
The Sexes sprung from Shame & Pride Blowd in the morn; in evening died But Mercy changed Death into Sleep; The Sexes rose to work & weep.
Thou Mother of my Mortal part. With cruelty didst mould my Heart. And with false self-deceiving tears. Didst blind my Nostrils Eyes & Ears
Didst close my Tongue in senseless clay And me to Mortal Life betray: The Death of Jesus set me free. Then what have I to do with thee?
Tirzah was a city in Biblical (Old Testament) times of wealth, pleasure, and (often) paganism-- much like the great cities of all major civilations become. Blake's "To Tirzah" comments on humanity's all-too-common frailty in falling into the sinfulness of Tirzah (worldliness)-- beginning with Eve (the mother of our "mortal parts"), and offers a hopeful message in the last 2 lines in stark contrast to the bleak truths the rest of the poem contains: that Christ's Resurrection has freed all humanity from Sin (Tirzah). Hence, "What have I to do with thee?"
Though Travis's biblical history is correct and William's wordery is very eliquent, I'd like to point out that perhaps there are anciant cities that are better knowen for there sins. I for one would prefer my name not to be used as a pretty way of saying sin.